肌少症和其共病的发病机制的研究

王 蕴哲, 张 树波, 臧 鹤然
河北省唐山市华北理工大学附属医院麻醉科

摘要


肌少症作为骨骼肌质量与功能进行性丧失的综合征，与很多慢性疾病存在密切关联，构成"疾病-肌少症"的恶性循环。本文系统解析其共性机制，为慢性疾病合并肌少症的精准防治提供理论依据。

关键词


肌少症；慢性疾病；炎症

全文:

PDF


参考


[1]Cruz-Jentoft A J, Sayer A A. Sarcopenia[J]. The Lancet, 2019, 393(10191): 2636-2646.

[2]Anker S D, Morley J E, Von Haehling S. Welcome to the ICD‐10 code for sarcopenia[J]. Journal of Cachexia, Sarcopenia and Muscle, 2016, 7(5): 512-514.

[3]Cruz-Jentoft A J, Bahat G, Bauer J, et al. Sarcopenia: revised European consensus on definition and diagnosis[J]. Age and Ageing, 2019, 48(1): 16-31.

[4]Roberts H C, Denison H J, Martin H J, et al. A review of the measurement of grip strength in clinical and epidemiological studies: towards a standardised approach[J]. Age and Ageing, 2011, 40(4): 423-429.

[5]Buckinx F, Landi F, Cesari M, et al. Pitfalls in the measurement of muscle mass: a need for a reference standard[J]. Journal of Cachexia, Sarcopenia and Muscle, 2018, 9(2): 269-278.

[6]Huang Y, Xu W, Zhou R. NLRP3 inflammasome activation and cell death[J]. Cellular and Molecular Immunology, 2021, 18(9): 2114-2127.

[7]Poehlman E T. Increased resting metabolic rate in patients with congestive heart failure[J]. Annals of internal medicine, 1994, 121(11): 860.

[8]Aquilani R, Opasich C, Verri M, et al. Is nutritional intake adequate in chronic heart failure patients?[J]. Journal of the American College of Cardiology, 2003, 42(7): 1218-1223.

[9]İlhan B, Bahat G, Erdoğan T, et al. Anorexia is independently associated with decreased muscle mass and strength in community dwelling older adults[J]. Journal of Nutrition, Health & Aging, 2019, 23(2): 202-206.

[10]Sandek A, Doehner W, Anker S D, et al. Nutrition in heart failure: an update:[J]. Current Opinion in Clinical Nutrition & Metabolic Care, 2009, 12(4): 384-391.

[11]Hussain Z, Swindle J, Hauptman P J. Digoxin Use and Digoxin Toxicity in the Post-DIG Trial Era[J]. Journal of Cardiac Failure, 2006, 12(5): 343-346.

[12]Gonzalez-Freire M, De Cabo R, Studenski S A, et al. The neuromuscular junction (NMJ): aging at the crossroad between nerves and muscle[J]. Frontiers in Aging Neuroscience, 2014, 6.

[13]Csapo R, Malis V, Sinha U, et al. Age-associated differences in triceps surae muscle composition and strength - an MRI-based cross-sectional comparison of contractile, adipose and connective tissue[J]. BMC Musculoskeletal Disorders, 2014, 15(1): 209.

[14]Ma K, Mallidis C, Artaza J, et al. Characterization of 5'-regulatory region of human myostatin gene: regula tion by dexamethasone in vitro[J]. American Journal of Physiology Endocrinology and Metabolism, 2001, 281(6): E 1128-E1136.

[15]Nan Y, Zhou Y, Dai Z, et al. Role of nutrition in patients with coexisting chronic obstructive pulmonary disease and sarcopenia[J]. Frontiers in Nutrition, 2023, 10: 1214684.

[16]Chen J, Splenser A, Guillory B, et al.Ghrelin prevents tumour‐and cisplatin‐induced muscle wasting: characterization of multiple mechanisms involved[J]. Journal of Cachexia,Sarcopenia and Muscle, 2015,6(2):132-143.


Refbacks

  • 当前没有refback。