巨噬细胞极化调控在溃疡性结肠炎黏膜修复中的分子机制研究进展

贾 雨娜, 朱 梅, 廖 飞, 张 露
西安培华学院

摘要


溃疡性结肠炎（UC）是慢性复发性炎症性肠病，现有抗炎策略难驱动黏膜修复与屏障重建。巨噬细胞极化是核心：M1促炎破黏膜，M2促修复建屏障。本综述聚焦极化关键分子机制（NF-κB、cGAS-STING通路及组蛋白乳酸化修饰），解析M2通过抗炎因子分泌、促血管生成、胞葬作用等与肠上皮细胞互作的修复网络，总结靶向极化治疗策略（小分子药物、纳米技术）并展望挑战与精准医疗方向，为UC发病机制研究及促黏膜愈合的精准免疫治疗提供理论依据。

关键词


溃疡性结肠炎；巨噬细胞极化；黏膜修复；信号通路；治疗策略

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参考


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