鞣花酸调控铁代谢干预缺铁性贫血的研究现状与展望

陈 雨婷, 孙 骁乐, 覃 诗妍, 刘 羽雪, 曾 欣怡, 夏 子茹, 祁 晓雪
新疆科技学院

摘要


缺铁性贫血（Iron Deficiency Anemia, IDA）是全球性的营养代谢性疾病，传统铁剂疗法常因胃肠道副作用及炎症状态下的铁吸收障碍而受限。现有证据表明，EA可通过抑制LPS-TLR4-NF-κB等炎症通路，下调铁调素表达，从而解除对膜铁转运蛋白的抑制，促进肠道铁吸收与巨噬细胞铁释放。同时，EA的肠道菌群代谢产物尿石素A不仅具有协同抗炎活性，还能通过改善线粒体功能增强造血干细胞活力。本文系统综述了鞣花酸（Ellagic Acid,EA）在改善IDA的潜在作用机制，重点从抗炎调节铁代谢、直接干预铁稳态核心靶点、以及调控肠道菌群三个维度进行梳理。

关键词


石榴皮；鞣花酸；缺铁性贫血；铁调素；抗炎作用；肠道菌群

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参考


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